Rise Health & Wellness Peptides

Binding to IRR: Targets the innate repair receptor (IRR), not the classical EPO receptor, to activate regenerative responses.

Activation of Tissue Protection Pathways: Stimulates anti-apoptotic and pro-repair mechanisms, enhancing cell survival and tissue restoration.

Anti-Inflammatory Effects: Reduces cytokines (TNF-α, IL-1β, IL-6) and inhibits inflammatory cell recruitment.

Neuropathic Pain Relief: Modulates pain and inflammation pathways, improving nerve function.

1. Small Fiber Neuropathy (SFN)

• Study focus: Sarcoidosis-associated SFN
• Key findings: Improved nerve fiber density and reduced pain
• Reference: Heij et al., Pain Medicine, 2012

2. Neuropathic Pain Relief

• Study focus: Diabetic neuropathy
• Key findings: Lowered pain scores; minimal side effects
• Reference: Brines et al., Molecular Medicine, 2015

3. Anti-Inflammatory Properties

• Study focus: Animal models of inflammatory disease
• Key findings: Decreased TNF-α, IL-1β, IL-6; protected tissues
• Reference: Brines et al., Science Translational Medicine, 2008

4. Kidney Protection

• Study focus: Renal ischemia-reperfusion injury in mice
• Key findings: Reduced oxidative stress and tissue damage
• Reference: van Velzen et al., Kidney International, 2014

5. Clinical Trials Summary

• Study focus: Multiple Phase II trials for neuropathic pain
• Key findings: Pain relief, nerve repair, minimal adverse events