NAD + (1000mg)

$145.00 USD

Rise Health

NAD⁺ (Nicotinamide Adenine Dinucleotide) is a vital coenzyme present in all living cells, critical to energy metabolism, DNA repair, mitochondrial function, and cellular signaling. It exists in oxidized (NAD⁺) and reduced (NADH) forms and plays a central role in aging, neurodegeneration, immunity, and metabolic health. As NAD⁺ levels decline with age, supplementation strategies (e.g., NMN, NR) are being explored to enhance healthspan and lifespan.

Current Research Focus ▼

Primary Research Areas:

Anti-aging and longevity enhancement
Neuroprotection (e.g., Alzheimer’s and Parkinson’s disease)
DNA repair and cellular resilience
Metabolic health (insulin sensitivity and fat metabolism)
Muscle recovery and exercise performance
Circadian rhythm and sleep regulation
Immune function and inflammation control

Mechanism of Action ▼

1. Sirtuin Activation: NAD⁺ serves as a critical cofactor for sirtuins, enzymes involved in aging regulation, gene expression, and cellular stress resistance.

2. DNA Repair via PARP: Enables PARP enzyme activity to repair DNA damage and maintain genomic stability.

3. Mitochondrial Energy Production: Facilitates redox reactions required for glycolysis, the TCA cycle, and oxidative phosphorylation, supporting efficient ATP generation.

4. AMPK and FOXO3 Pathway Support: Indirectly enhances metabolic efficiency and longevity-associated signaling pathways.

5. Inflammation Modulation: Helps regulate pro-inflammatory cytokines and supports immune system balance.

Key Research Studies ▼

1. NAD⁺ Restoration and Aging

Study focus: NAD⁺ enhancement and lifespan
Key findings: Boosting NAD⁺ extended lifespan and improved muscle and brain function
Reference: Nature Communications
Link: View Study

2. Neurodegeneration and Alzheimer’s Models

Study focus: NAD⁺ in cognitive decline
Key findings: Reduced neuroinflammation and preserved memory function
Reference: Nature Communications
Link: View Study

3. Metabolic Regulation

Study focus: NAD⁺ precursors and insulin sensitivity
Key findings: Nicotinamide riboside (NR) improved metabolic markers and mitochondrial health
Reference: Science Advances
Link: View Study

4. DNA Repair and Oxidative Stress

Study focus: Enhancement of cellular repair mechanisms
Key findings: NAD⁺ boosted PARP activity and reduced oxidative damage
Reference: PubMed ID 35697437
Link: View Abstract

5. Published Clinical Studies

NR improved blood pressure in older adults – Nature Communications, 2018
NR raised NAD⁺ levels in humans – Nature Communications, 2016
NMN improved insulin sensitivity in prediabetics – Science, 2021
NMN enhanced endurance in older men – ClinicalTrials.gov

6. Ongoing Clinical Trials

NR in Alzheimer’s disease – NCT03482167
NMN and aging biomarkers – NCT03151239
NR in heart failure – NCT04330390
NMN in metabolic function – ClinicalTrials.gov

Biological Effects and Benefits

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Energy Production (ATP Synthesis):

Essential for cellular respiration and mitochondrial function. Transfers electrons to power ATP production, the body's primary energy source.

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DNA Repair & Cell Longevity:

Acts as a cofactor for PARPs involved in DNA repair, helping prevent mutations and age-related cellular damage.

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Sirtuin Activation (Longevity & Aging):

Activates NAD+-dependent sirtuins that regulate gene expression, metabolism, and stress resistance, supporting cellular resilience and reduced inflammation.

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Neuroprotection & Cognitive Function:

Supports neuronal survival, synaptic plasticity, and inflammation control, helping protect against cognitive decline.

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Metabolic Regulation & Insulin Sensitivity:

Influences glucose metabolism and lipid oxidation, enhancing fat breakdown and supporting healthy metabolic function.

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Redox Reactions & Antioxidant Defense:

Cycles between NAD+ and NADH in redox reactions to neutralize free radicals and reduce oxidative stress.

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Circadian Rhythm Regulation:

Regulates clock genes, aligning metabolism with sleep-wake cycles and supporting overall metabolic balance.

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Immune Function & Inflammation Control:

Modulates immune cell activity and inflammatory responses, supporting anti-inflammatory pathways.

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Muscle Health & Physical Performance:

Enhances mitochondrial biogenesis, endurance, and recovery, supporting improved exercise performance and muscle regeneration.

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