Rise Health & Wellness Peptides

BPC-157 + TB-500 (10mg/10mg)
$135.00 USD
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Rise Health

BPC-157 and TB-500 are two peptides widely researched in regenerative medicine and sports rehabilitation. BPC-157 is a synthetic pentadecapeptide derived from a protein found in gastric juice, while TB-500 is a synthetic version of Thymosin Beta-4. Each peptide promotes healing through distinct mechanisms, with BPC-157 enhancing angiogenesis and reducing inflammation, and TB-500 facilitating cellular migration and tissue repair. Used together, they may offer a synergistic effect in supporting tissue regeneration, soft tissue recovery, and inflammation control.BPC-157 is a synthetic pentadecapeptide (15 amino acids) derived from a protective protein found in human gastric juice. It is renowned for its powerful regenerative and healing effects, especially in muscles, tendons, ligaments, nerves, and the gastrointestinal tract. Its systemic healing capabilities, anti-inflammatory effects, and ability to promote angiogenesis have made it widely studied and used in regenerative medicine and sports recovery.

Current Research Focus ▼
  • Musculoskeletal injuries (tendon, ligament, and muscle damage)
  • Post-surgical wound healing and scar reduction
  • Chronic inflammatory conditions (e.g., arthritis, Crohn’s disease, fibromyalgia)
  • Neuroprotection (e.g., traumatic brain injury, neurodegeneration)
  • Cardiac repair (e.g., recovery after myocardial infarction)
Mechanism of Action ▼

BPC-157 – Angiogenesis and Inflammation Control: Promotes VEGF expression for blood vessel growth and downregulates pro-inflammatory cytokines.

BPC-157 – Growth Factor Stimulation: Activates fibroblasts and upregulates TGF-β to support tissue repair.

BPC-157 – Gut-Brain Axis Support: May aid gastrointestinal integrity and support neurological health.

TB-500 – Cell Migration and Differentiation: Increases actin polymerization, enhancing cell movement to injury sites.

TB-500 – Anti-Fibrotic Effects: Reduces scar tissue formation by modulating CTGF activity.

TB-500 – Inflammation Modulation: Balances immune responses to promote efficient tissue healing.

Key Research Studies ▼

BPC-157

1. Sikiric et al., 2018

  • Study focus: Healing and gastrointestinal tract lesions
  • Key findings: Supports angiogenesis and reduces inflammation
  • Journal: Current Pharmaceutical Design
  • Link: PMC5855565

2. Sikiric et al., 2020

  • Study focus: Effects beyond gastrointestinal healing
  • Key findings: Demonstrated cardiovascular and neurological repair potential
  • Journal: World Journal of Gastroenterology
  • Link: PMC7138176

3. Petrovic et al., 2017

  • Study focus: Tendon and ligament healing
  • Key findings: Promoted tendon-to-bone healing and musculoskeletal recovery
  • Journal: Journal of Applied Physiology

TB-500 (Thymosin Beta-4)

4. Goldstein et al., 2012

  • Study focus: Tissue repair and wound healing
  • Key findings: Enhanced cell migration and modulated inflammation
  • Journal: Annals of the New York Academy of Sciences
  • Link: 22385966

5. Badamchian et al., 2009

  • Study focus: Angiogenesis and tissue regeneration
  • Key findings: Supported immune modulation and blood vessel growth
  • Journal: Molecular and Cellular Biochemistry
  • Link: 19458982

6. Philp et al., 2007

  • Study focus: Dermal wound healing
  • Key findings: Accelerated wound closure and reduced fibrosis
  • Journal: The Journal of Investigative Dermatology
  • Link: 17380120

Combined Use

  • Study focus: Combined effects on tendon and ligament healing
  • Key findings: Anecdotal and equine studies suggest faster and more complete recovery
  • Note: No direct human studies yet; proposed mechanisms appear complementary

Additional Research Resources:

Biological Effects and Benefits
✓
Accelerated Healing:
Speeds up recovery of muscles, tendons, ligaments, and bones. Promotes faster post-surgical or injury recovery.
✓
Gut Health Support:
Helps heal ulcers, leaky gut, and inflammatory bowel conditions such as Crohn’s or colitis. Protects the GI lining from damage caused by NSAIDs, alcohol, or stress.
✓
Anti-Inflammatory Effects:
Reduces inflammation and pain in injured or overused tissues. May support chronic inflammatory conditions.
✓
Joint and Soft Tissue Repair:
Supports cartilage, ligament, and joint healing, making it popular in sports medicine. Can be used locally or systemically for targeted healing.
Biological Effects
✓
Neuroprotective Properties:
Potentially helps with nerve regeneration and protection against brain injury or neurodegeneration.
✓
Cardiovascular and Vessel Protection:
Promotes angiogenesis (formation of new blood vessels), supporting circulation and wound healing. Protects blood vessels from oxidative stress.
✓
Skin and Wound Repair:
Enhances wound healing in burns, cuts, and abrasions. Supports collagen production and regeneration.

Biological Effects and Benefits

BPC157
Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Molecular Formula: C₆₂H₉₈N₁₆O₂₂
Molecular Weight≈ 1419.5 g/mol
‍
TB-500
Sequence: N-Acetyl-Leu-Lys-Lys-Thr-Glu-Thr-Gln (Ac-LKKTETQ)
Molecular Formula= C₂₁₂H₃₅₀N₅₆O₇₈S
Molecular Weight ≈ 4,963.4 g/mol

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