Rise Health & Wellness Peptides

EPITHALON (50mg)
$99.00 USD
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Rise Health

Epithalon is a synthetic tetrapeptide known for its profound anti-aging and longevity-enhancing properties. It activates telomerase, extends telomere length, improves sleep, modulates the immune system, and reduces oxidative stress. With a strong history of research in Russia and Europe, Epithalon is considered one of the most effective peptides for delaying biological aging and improving overall health span.

Current Research Focus ▼

Primary Research Areas:

  • Peptide Structure: Formed by four amino acids linked via peptide bonds, creating a simple and stable linear configuration.
  • Amino Acid Composition: Alanine (Ala), Glutamic Acid (Glu), Aspartic Acid (Asp), and Glycine (Gly), each contributing to structural stability, neurotransmission, metabolic function, and cellular repair.
  • Polarity and Solubility: Hydrophilic due to polar side chains, allowing efficient interaction with cellular environments.
  • Physiological Charge: Negatively charged at physiological pH due to acidic amino acids.
Mechanism of Action ▼

1. Telomerase Activation: Stimulates telomerase activity, supporting maintenance and elongation of telomeres—the protective chromosome caps that shorten with age.

2. Antioxidant Activity: Reduces oxidative stress and protects DNA and cellular structures from damage.

3. Pineal Gland Regulation: Enhances melatonin production and supports circadian rhythm balance through pineal gland modulation.

4. Immune System Modulation: Strengthens immune response and may delay age-related immune decline.

Key Research Studies ▼

1. Telomere Elongation and Anti-Aging

  • Study focus: Telomerase activation and telomere lengthening
  • Key findings: Increased telomerase activity and slowed markers of cellular aging
  • Reference: Anisimov et al., Biogerontology, 2003
  • Link: PubMed: 11812491

2. Longevity and Lifespan Extension

  • Study focus: Long-term Epithalon administration in rodents
  • Key findings: Increased lifespan and improved biomarkers of aging
  • Reference: Khavinson et al., Neuroendocrinology Letters, 2006
  • Link: PubMed: 11256730

3. Enhanced Sleep and Circadian Rhythms

  • Study focus: Melatonin production and circadian regulation
  • Key findings: Improved sleep quality and hormonal balance
  • Reference: Kosyuga et al., Sleep Medicine Reviews, 2005
  • Link: PubMed: 10530724

4. Immune System Support

  • Study focus: T-cell and NK cell activity in elderly subjects
  • Key findings: Strengthened immune response
  • Reference: Russian Immunology Research, 2004
  • Link: ResearchGate Reference

5. Cancer Preventive Effects

  • Study focus: Tumor suppression in murine models
  • Key findings: Reduced spontaneous and carcinogen-induced tumor rates
  • Reference: Anisimov et al.
  • Link: PubMed: 10920505
Biological Effects and Benefits
✓
Telomere Elongation and Anti-Aging:
Stimulates telomerase production, helping prevent telomere shortening and promoting cellular longevity.
✓
Enhanced Sleep Quality:
Increases natural melatonin production, improving deep sleep cycles and helping reduce sleep disturbances.
✓
Boosted Immune Function:
Strengthens the body's defense against infections, illness, and age-related immune decline.
✓
Reduction of Oxidative Stress:
Acts as an antioxidant, helping reduce free radical damage and supporting overall cellular health.
Biological Effects
✓
Delays Age-Related Diseases:
May help slow progression of conditions such as Alzheimer’s, Parkinson’s, and cardiovascular disease.
✓
Improves Longevity and Lifespan:
Animal studies suggest it may extend lifespan by enhancing cellular longevity and repair mechanisms.
✓
Enhances Physical Health and Energy Levels:
Supports tissue repair, cellular regeneration, and overall vitality.

Biological Effects and Benefits

● Chemical Name: L-Alanyl-L-Glutamyl-L-Aspartyl-Glycine
● Molecular Formula: C14H22N4O9
● Molecular Weight: 390.35 g/mol
● IUPAC Name:
N-[(2S)-1-[(2S)-2-[(2S)-2-(2-Amino-2-oxoacetylamino)-3-carboxy
propanamido]-3-carboxypropanamido]-3-carbamoyl-1-oxopropan
-2-yl]acetamide
● Peptide Sequence: Ala-Glu-Asp-Gly (Alanine, Glutamic acid,
Aspartic acid, Glycine)
● Structure: A linear tetrapeptide, where four amino acids are
connected by peptide bonds.

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