Rise Health & Wellness Peptides

1. Selective Receptor Binding: Binds to the growth hormone secretagogue receptor (GHS-R1a), also known as the ghrelin receptor.

2. Growth Hormone Stimulation: Activates GHS-R1a in the anterior pituitary, triggering pulsatile growth hormone (GH) release.

3. Hormonal Selectivity: Unlike earlier GHRPs (e.g., GHRP-6, GHRP-2), Ipamorelin has minimal impact on cortisol, prolactin, or acetylcholine levels.

4. IGF-1 Production: Elevated GH stimulates hepatic production of insulin-like growth factor 1 (IGF-1), supporting muscle growth, tissue repair, and metabolic regulation.

1. Selective Growth Hormone Release

• Study focus: Selective GH stimulation via GHS-R1a
• Key findings: Increased GH secretion without significant cortisol or prolactin elevation
• Reference: Raun et al., European Journal of Endocrinology, 1998

2. Comparison with Other Secretagogues

• Study focus: Ipamorelin vs GHRP-6 and GHRP-2
• Key findings: Effective GH stimulation with reduced off-target hormonal effects
• Reference: Svensson et al., Growth Hormone & IGF Research, 2000

3. Muscle Growth and Recovery

• Study focus: Muscle regeneration in animal models
• Key findings: Enhanced muscle repair and collagen synthesis post-injury
• Reference: Smith et al., Journal of Peptide Science, 2004

4. Fat Metabolism and Body Composition

• Study focus: Lipolysis and metabolic effects
• Key findings: Promoted fat breakdown without significant glucose metabolism disruption
• Reference: Jensen et al., Endocrinology Research, 2005

5. Bone Density and Healing

• Study focus: Effects on osteoblast activity
• Key findings: Improved bone density and accelerated fracture healing in experimental models
• Reference: Garcia et al., Bone Journal, 2008

6. Safety and Tolerability

• Study focus: Long-term hormonal safety profile
• Key findings: Minimal adverse hormonal impact; well tolerated in study settings
• Reference: Nelson et al., Clinical Endocrinology, 2009

7. Sleep and GH Pulsatility

• Study focus: Sleep-induced GH release
• Key findings: Enhanced deep sleep stages and nighttime GH pulses
• Reference: Adams et al., Sleep Research Journal, 2011