Rise Health & Wellness Peptides

KISSPEPTIN (10mg)
$150.00 USD
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Rise Health

Kisspeptin is a neuropeptide hormone that plays a central role in the regulation of the reproductive hormone axis. It acts as a master regulator of gonadotropin-releasing hormone (GnRH) by binding to the KISS1 receptor (GPR54) in the hypothalamus. This triggers the release of GnRH, which subsequently stimulates the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), governing sex hormone production and reproductive function. Kisspeptin is increasingly recognized for its therapeutic potential in fertility, puberty regulation, and hormone restoration.

Current Research Focus ▼

Primary Research Areas:

  • Natural stimulation of sex hormone production (testosterone, estrogen, progesterone)
  • Male and female fertility support (e.g., ovulation, sperm production)
  • Hormone restoration during HRT while preserving fertility
  • Treatment of delayed or disordered puberty
  • Management of hypogonadotropic hypogonadism
  • Potential applications in assisted reproductive technology (ART)
Mechanism of Action ▼

1. Receptor Binding (KISS1R): Binds to the KISS1 receptor (GPR54) in the hypothalamus, primarily on GnRH neurons.

2. Intracellular Calcium Signaling: Activates G-protein pathways, triggering phospholipase C (PLC) and increasing intracellular Ca²⁺, leading to depolarization of GnRH neurons.

3. GnRH Release: Stimulates pulsatile release of gonadotropin-releasing hormone (GnRH), promoting LH and FSH secretion from the pituitary.

4. Downstream Hormonal Cascade: LH and FSH act on the gonads to stimulate sex hormone production and regulate fertility.

5. Hormonal Feedback Regulation: Estrogen and testosterone modulate kisspeptin signaling to maintain endocrine balance; metabolic stress may influence activity.

Key Research Studies ▼

1. Fertility Regulation via GnRH Stimulation

  • Findings: Increased GnRH, LH, and FSH levels, supporting ovulation and spermatogenesis.
  • Clinical Insight: Demonstrated potential as an alternative to GnRH agonists/antagonists in fertility therapies.
  • Reference: PubMed ID 21310881
  • Link: View Study

2. Hypogonadotropic Hypogonadism Treatment

  • Findings: Restored reproductive hormone levels in individuals with GnRH deficiency.
  • Implication: Potential therapeutic application in male and female fertility disorders.
  • Reference: PubMed ID 21262681
  • Link: View Study
Biological Effects and Benefits
✓
Stimulates Natural Hormone Production:
Activates GnRH release, increasing LH and FSH levels to naturally boost testosterone or estrogen production.
✓
Supports Fertility in Men and Women:
In women, it may help regulate cycles and induce ovulation. In men, it can support testicular function and stimulate sperm production.
Biological Effects
✓
Preserves and Enhances Fertility During HRT:
Unlike traditional hormone therapy, it supports the body's own hormone production, helping maintain fertility.
✓
Promotes Pubertal Development:
Helps initiate and regulate puberty in adolescents with delayed or disordered sexual development.

Biological Effects and Benefits

Sequence: YNWNSFGLRF (Tyrosine-Asparagine-Tryptophan-Asparagine-Serine-Phenylalanine-Glycine-Leucine-Arginine-Phenylalanine)

Molecular Formula: C63H83N17O14

Molecular Weight: ~6,000–6,200 Da (≈6.1 kDa)

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