Rise Health & Wellness Peptides

1. Melanocortin Receptor Activation: Binds to MC1R (pigmentation) and MC3R/MC4R (libido, appetite, metabolism).

2. Melanin Production via MC1R: Activates the cAMP signaling pathway, increasing tyrosinase activity and stimulating eumelanin (dark pigment) synthesis.

3. Libido and Erectile Function: MC4R stimulation in the hypothalamus promotes dopamine release and enhances sexual arousal.

4. Appetite Regulation: Interaction with hypothalamic MC4R reduces hunger signaling and may support metabolic rate enhancement.

5. UV Protection: Increased melanin production acts as a natural photoprotective barrier, limiting UV-induced skin damage.

1. Skin Pigmentation and UV Protection

• Study focus: MT2’s impact on tanning and UV resistance
• Key findings: Enhanced melanin production and long-lasting pigmentation with minimal sun exposure; reduced sunburn risk
• Reference: Annals of the New York Academy of Sciences, 2006

2. Erectile Dysfunction & Libido Enhancement

• Study focus: Effectiveness in men with erectile dysfunction
• Key findings: Improved erectile function and sexual arousal via MC4R stimulation
• Reference: International Journal of Impotence Research, 2000

3. Appetite Suppression and Fat Loss

• Study focus: Appetite and weight regulation in animal models
• Key findings: Reduced food intake and modest fat loss mediated through hypothalamic MC4R pathways
• Reference: Endocrinology, 2004

4. Anti-Inflammatory and Metabolic Benefits

• Study focus: Broader metabolic and inflammatory effects
• Key findings: Potential improvement in insulin sensitivity and reduction of obesity-related inflammation
• Reference: Nature Communications, 2019