Rise Health & Wellness Peptides

Sermorelin (10mg)
$110.00 USD
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Rise Health

Sermorelin is a synthetic peptide that functions as a growth hormone-releasing hormone (GHRH) analog. It is composed of the first 29 amino acids of the natural human GHRH, making it capable of stimulating the pituitary gland to secrete endogenous growth hormone (GH). This peptide is often used in cases of GH deficiency and as part of anti-aging or wellness protocols due to its ability to naturally enhance GH production without suppressing the body’s feedback mechanisms.

Current Research Focus

Primary Research Areas:

  • Growth hormone deficiency
  • Anti-aging and vitality enhancement
  • Lean muscle mass increase and fat loss
  • Sleep improvement and recovery optimization
  • Metabolic health optimization
  • Cardiovascular recovery support
  • Neurological health and seizure regulation
Mechanism of Action

1. Pituitary Stimulation: Mimics natural growth hormone–releasing hormone (GHRH) by binding to GHRH receptors in the pituitary, increasing growth hormone secretion.

2. IGF-1 Activation: Indirectly elevates insulin-like growth factor 1 (IGF-1), supporting tissue growth, repair, and metabolic balance.

3. Pulsatile GH Release: Promotes rhythmic growth hormone pulses, preserving physiological feedback mechanisms and endocrine balance.

4. Neurochemical Interaction: Influences neurotransmitters such as GABA and orexin, contributing to mood stabilization and sleep regulation.

Key Research Studies

1. Cardiovascular Benefits

  • Study focus: Post–myocardial infarction recovery
  • Key findings: Reduced cardiomyocyte death, enhanced capillary growth, decreased inflammation, and improved diastolic function
  • Reference: Peptide Sciences
  • Link: View Study

2. Neurological Effects

  • Study focus: Seizure suppression and neuroregulation
  • Key findings: Activation of GABA-related pathways, suggesting potential benefit in epilepsy research
  • Reference: Peptide Sciences
  • Link: View Study

3. Sleep Regulation

  • Study focus: Hormonal modulation of sleep cycles
  • Key findings: Improved sleep quality via orexin pathway modulation and enhanced endogenous GH secretion
  • Reference: Peptide Sciences
  • Link: View Study

4. Hormonal Feedback Mechanism

  • Study focus: Physiological GH pulse preservation
  • Key findings: Stimulated growth hormone release in a pulsatile pattern, maintaining pituitary responsiveness and reducing overstimulation risk
Biological Effects and Benefits
Growth Hormone Deficiency Support:
Stimulates endogenous growth hormone release and is primarily used in cases of growth hormone deficiency.
Anti-Aging Support:
May help restore youthful vitality, energy levels, and muscle tone as natural growth hormone levels decline with age.
Biological Effects
Improved Metabolic Health:
May enhance fat metabolism and body composition by increasing lean muscle mass and reducing body fat.
Enhancement of Sleep:
Supports natural growth hormone rhythms, which may help improve overall sleep quality.

Biological Effects and Benefits

Sequence: Ala-His-Asp-Val-Gln-Asp-Glu-Gln-Val-Ala-Glu-Asn-Gln-Val-Asn-Gln-Leu-Ile-Gly-Asp-Lys-Gln-Asn-Thr-Tyr-Glu-Asn-His-Ser-Gly-Lys

Molecular Formula: C149H246N44O42

Molecular Weight: Approximately 3357.5 Daltons

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