Rise Health & Wellness Peptides

1. GHRH Receptor Activation: Binds to growth hormone–releasing hormone (GHRH) receptors in the anterior pituitary, stimulating endogenous growth hormone secretion.

2. Increased GH and IGF-1 Secretion: Elevated GH enhances lipolysis, while IGF-1 supports muscle growth, repair, and metabolic regulation.

3. Selective Fat Reduction: Promotes fat oxidation, particularly targeting visceral abdominal adipose tissue while preserving lean mass.

1. Visceral Fat Reduction in HIV Lipodystrophy

• Study focus: Tesamorelin vs placebo over 26 weeks
• Key findings: 15–20% reduction in visceral adipose tissue with no significant subcutaneous fat loss
• Reference: OUP Academic

2. Improved Lipid Profiles

• Study focus: Effects on blood lipid markers
• Key findings: Lower triglycerides and improved cholesterol ratios
• Reference: OUP Academic

3. Liver Fat Reduction (NAFLD Relevance)

• Study focus: Effect on hepatic fat in HIV patients
• Key findings: Up to 37% relative reduction in liver fat over 12 months
• Reference: JAMA Network; The Lancet HIV

4. Sustained VAT Reduction

• Study focus: 52-week treatment extension
• Key findings: Maintained visceral fat reduction and improved lipid profiles with continued therapy
• Reference: NATAP; PubMed

5. Neutral Effects on Glucose Metabolism

• Study focus: Glucose tolerance over time
• Key findings: No clinically significant changes in glucose or insulin markers
• Reference: OUP Academic; PubMed