Rise Health & Wellness Peptides

Thymosin Alpha-1 (10mg)
$125.00 USD
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Rise Health

Thymosin Alpha-1 is a naturally occurring peptide composed of 28 amino acids, originally derived from prothymosin alpha in the thymus gland. It plays a key role in immune regulation, particularly in T-cell maturation and immune response coordination. Tα1 is used therapeutically to enhance immune function in immunocompromised individuals, support vaccine efficacy, and assist in the treatment of viral, bacterial, and autoimmune conditions.

Current Research Focus ▼

Primary Research Areas:

  • Immune system modulation and support
  • Antiviral therapy (HBV, HCV, HIV, influenza, COVID-19)
  • Autoimmune disease regulation (RA, lupus, MS, IBD)
  • Sepsis and bacterial/fungal infection support
  • Immune restoration in elderly or immunocompromised individuals (post-chemotherapy, transplant patients, HIV/AIDS)
  • Vaccine response enhancement
Mechanism of Action ▼

1. T-Cell Activation: Stimulates maturation and differentiation of helper (CD4⁺) and cytotoxic (CD8⁺) T-cells, strengthening adaptive immune responses.

2. Dendritic and Macrophage Activation: Enhances antigen presentation and pathogen recognition, improving immune surveillance.

3. Cytokine Regulation: Promotes production of key immune mediators such as interferon-α (IFN-α) and interleukin-2 (IL-2), supporting antiviral activity.

4. Anti-Inflammatory Activity: Helps maintain immune homeostasis by modulating excessive cytokine release and reducing risk of cytokine storm.

Key Research Studies ▼

1. Immune Enhancement & Modulation

  • Study focus: Immune stimulation in immunodeficient patients
  • Key findings: Enhanced T-cell activity, improved dendritic cell function, and increased vaccine responsiveness
  • Reference: PubMed ID 33362999
  • Link: View Study

2. Sepsis Treatment

  • Study focus: Mortality reduction in septic patients
  • Key findings: Mixed clinical results; potential benefit observed in older or chronically ill patients, though some studies showed no significant mortality improvement
  • Reference: BMJ, 2024
  • Link: View Study
Biological Effects and Benefits
✓
Immune System Enhancement:
Stimulates CD4+ and CD8+ T-cell activation and differentiation to strengthen adaptive immunity. Enhances dendritic cell and macrophage function for improved pathogen recognition and clearance. Boosts natural killer (NK) cell activity while helping regulate immune homeostasis and balancing the Th1/Th2 response.
✓
Antiviral and Antimicrobial Properties:
Enhances immune response against viral infections including HBV, HCV, HIV, influenza, and COVID-19 by increasing interferon-alpha (IFN-α) production. Supports defense against bacterial infections such as sepsis and tuberculosis and helps protect against fungal pathogens.
Biological Effects
✓
Anti-Inflammatory & Autoimmune Regulation:
Modulates cytokine production to balance pro- and anti-inflammatory responses, helping prevent excessive inflammation and cytokine storms. May support regulation in autoimmune conditions such as rheumatoid arthritis, lupus, multiple sclerosis, and inflammatory bowel disease.
✓
Immune Restoration in Immunocompromised Patients:
Supports immune recovery in immunodeficient individuals including HIV/AIDS, post-transplant, chemotherapy-treated, and elderly patients. May also enhance vaccine responsiveness in immunosuppressed populations.

Biological Effects and Benefits

Sequence: Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH

Molecular Formula: C129H215N33O55

Molecular Weight: ~3,108 Da

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